منابع مشابه
Potentially Capable but not Actual
Many senrice courses in statistics, in my experience, have degenerated into the presentation of a set of recipes. The prevailing situation extant in many courses was summed up recently by my son, himself a trainee engineer, when he said, "I lean the recipes to pass the exam but I don't really understand the material". In fact the rapidity with which the material in his course has been presented...
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In this work, we present Sparse Distributed Memory for Small Cues (SDMSCue), a new variant of Sparse Distributed Memory (SDM) that is capable of handling small cues. SDM is a content-addressable memory technique that relies on similar memory items tending to be clustered together in the same region or subspace of the semantic space. SDM has been used before as associative memory or control stru...
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Complexins are synaptic SNARE complex-binding proteins that cooperate with synaptotagmins in activating Ca(2+)-stimulated, synaptotagmin-dependent synaptic vesicle exocytosis and in clamping spontaneous, synaptotagmin-independent synaptic vesicle exocytosis. Here, we show that complexin sequences are conserved in some non-metazoan unicellular organisms and in all metazoans, suggesting that comp...
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Ribbon synapses in retinal sensory neurons maintain large pools of readily releasable synaptic vesicles. This allows them to release several hundreds of vesicles per second at every presynaptic release site. The molecular components that cause this high transmitter release efficiency of ribbon synapses are unknown. In the present study, we identified and characterized two novel vertebrate compl...
متن کاملComplexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release
Synaptic vesicle fusion at synapses is triggered by increases in cytosolic Ca2+ levels. However, the identity of the Ca2+ sensor and the transduction mechanism of the Ca2+ trigger are unknown. We show that Complexins, stoichiometric components of the exocytotic core complex, are important regulators of transmitter release at a step immediately preceding vesicle fusion. Neurons lacking Complexin...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2015
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-015-1998-8